Isolated glomerulonephritis with mesangial IgA deposits Br Med J 3http:/

Top of pageAbstractImmunologic studies in IgA nephropathy,tods pas cher. Circulating immune complexes (CIC) were detected in 43.6% of 78 patients with primary IgA nephropathy by the solid-phase Clq radioimmunoassay. The IC were intermediate (9 to 17S) in size and contained IgA,tods pas cher, IgG,chaussures pas cher, and less commonly IgM. CIC were often present intermittently, correlating with episodes of macroscopic hematuria. Elevated serum IgA concentrations (38.7%) did not correlate with the detection of CIC. Similar findings were observed in sera samples from patients with Henoch Schonlein purpura and in IgA glomerulonephritis associated with alcoholic cirrhosis and/or portal systemic shunts,mercurial Vapor pas cher. The factors responsible for the mesangial localization of the IC are not clear, but elevations in serum antibody titers to respiratory pathogens (mycoplasma pneumoniae, herpes virus, influenza), gut flora (E, coli 07),tod’s femme, and bovine serum albumin suggest that common exogenous antigens may be involved in the pathogenesis,puma pas cher. Primary defects in either mucosal antigen exclusion or reticuloendothelial IC sequestration are proposed to account for these findings,tods chaussures.

Etudes immunologiques dans la n IgA,tods sale. Des immuns complexes circulants (CIC) ont d dans 43,6% des 78 malades atteints de n IgA au moyen du dosage radio-immunologique de Clq en phase solide. Ces immuns complexes sont de taille interm (9 17 S) et contiennent de l’lgA de l’IgG et, de fa moins fr de l’IgM,chaussures puma. Les CIC ne sont souvent pr que de fa intermittente, en corr avec les d’h macroscopique,chaussures pas cher. Les concentrations d’IgA s (38,7%) ne sont pas corr avec la pr de CIC,tods sale. Des constatations similaires ont faites dans le s de malades atteints de purpura de Henoch Schonlein et dans la glom IgA associ la cirrhose alcoolique et/ou aux d portales. Les facteurs responsables de la localisation m de IC ne sont pas clairs mais les du titre des anticorps s aux agents pathog respiratoires (mycoplasma pneumonia, virus de l’herp influenza), la flore intestinale (E. coli 07) et la s albumine bovine sugg que des anticorps exog tr r peuvent impliqu dans la pathog Des d primaires soit de l’exclusion muqueuse des antig soit de la s r des IC sont propos pour rendre compte de ces constatations.

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